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Title: Circadian variation in cardiac autonomic activity: Reactivity measurements to different types of stressors
Author(s): A.P.J. van Eekelen, J.H. Houtveen and G.A. Kerkhof
Journal: Chronobiology International
Year: 2004
Volume: 21
Issue: 1
Pages: 107--129
Publisher address: Univ Amsterdam, Dept Psychol, NL-1018 WB Amsterdam, Netherlands Univ Utrecht, Dept Hlth Psychol, NL-3508 TC Utrecht, Netherlands MCH Westeinde, Ctr Sleep & Wake Disorders, The Hague, Netherlands
ISSN: 0742-0528
File URL: vuams-pubs/Van_Eekelen_2004.pdf
Keywords: BLOOD-PRESSURE, Body Temperature, circadian rhythmicity, circadian variation, constant routine, constant routines, CONSTANT-ROUTINE, core body temperature, DISORDER, DISORDERS, Drive, endogenous, Heart Rate, HEART-RATE REACTIVITY, IMMUNE-RESPONSES, INDIVIDUAL-DIFFERENCES, MYOCARDIAL-ISCHEMIA, Netherlands, NEUROENDOCRINE, parasympathetic activity, REACTIVITY, regression, RESPIRATORY SINUS ARRHYTHMIA, RHYTHM, Sleep, stress reactivity, SUPRACHIASMATIC NUCLEUS, sympathetic activity, TEMPERATURE, Time, Wakefulness
Abstract: The role of endogenous circadian rhythmicity in autonomic cardiac reactivity to different stressors was investigated. A constant routine protocol was used with repeated exposure to a dual task and a cold pressor test. The 29 subjects were randomly divided into two groups in order to manipulate prior wakefulness. Group 1 started at 09:00h immediately after a monitored sleep period, whereas group 2 started 12 h later. Measures of interbeat intervals (IBI), respiratory sinus arrythmia (RSA, a measure of parasympathetic activity), pre-ejection period (PEP, a measure of sympathetic activity), as well as core body temperature (CBT) were recorded continuously. Multilevel regression analyses (across-subjects) revealed significant (mainly 24h) sinusoidal circadian variation in the response to both stressors for IBI and RSA, but not for PEP. Individual 24 + 12 h cosine fits demonstrated a relatively large interindividual variation of the phases of the IBI and RSA rhythms, as compared to that of the CBT rhythm. Sinusoidal by group interactions were found for IBI and PEP, but not for RSA. These findings were interpreted as an indication for endogenous circadian and exogenous parasympathetic (vagal) modulation of cardiac reactivity, while sympathetic reactivity is relatively unaffected by the endogenous circadian drive and mainly influenced by exogenous factors

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