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Title: Association Between Depression, Anxiety, and Antidepressant Use With T-Wave Amplitude and QT-Interval
Author(s): Mandy X. Hu, Femke Lamers, Brenda W.J.H. Penninx and Eco J.C. de Geus
Journal: Frontiers in Neuroscience
Year: 2018
Month: June
Day: 5
Volume: 12
DOI: 10.3389/fnins.2018.00375
File URL: /vuams-pubs/Association_between_depression__anxiety__and_antidepressant_use_with_t-wave_amplitude_and_QT-interval.pdf
Keywords: autonomic nervous system, cardiac repolarization, depression, anxiety, antidepressant
Abstract: Objectives: Cardiac repolarization may be affected by psychiatric disorders and/or antidepressant use, but evidence for this is inconclusive. This study examined the relationship between depressive and anxiety disorder and use of antidepressants with T-wave amplitude (TWA) and QT-interval. Methods: Data was obtained from the Netherlands Study of Depression and Anxiety (n = 1,383). Depression/anxiety was diagnosed with the DSM-IV based Composite International Diagnostic Interview. The use of tricyclic antidepressants (TCAs), selective serotonin and noradrenalin reuptake inhibitors (SNRIs), and selective serotonin reuptake inhibitors (SSRIs) was established. T-wave amplitude and QT-interval corrected for heart rate (QTc) were obtained from an ECG measured in a type II axis configuration. Results: Compared to controls, persons with depression or anxiety disorders did not show a significantly different TWA (p = 0.58; Cohen’s d = 0.046) or QTc (p = 0.48; Cohen’s d = ?0.057). In spite of known sympathomimetic effects, TCA use (p = 0.26; Cohen’s d =?0.162) and SNRI use (p=0.70; Cohen’s d =?0.055) were not significantly associated with a lower TWA. TCA use (p = 0.12; Cohen’s d = 0.225) and SNRI use (p = 0.11; Cohen’s d = 0.227) were also not significantly associated with a prolonged QTc. Conclusion: We did not find evidence that either depressive/anxiety disorder or antidepressant use is associated with abnormalities in TWA or QTc. Earlier found sympathomimetic effects of TCAs and SNRIs are not evident in these measures of cardiac repolarization.

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