||Association Between Depression, Anxiety, and Antidepressant Use With T-Wave Amplitude and QT-Interval
, , and |
||Frontiers in Neuroscience
||autonomic nervous system, cardiac repolarization, depression, anxiety, antidepressant
||Objectives: Cardiac repolarization may be affected by psychiatric disorders and/or antidepressant use, but evidence for this is inconclusive. This study examined the relationship between depressive and anxiety disorder and use of antidepressants with T-wave amplitude (TWA) and QT-interval.
Methods: Data was obtained from the Netherlands Study of Depression and Anxiety (n = 1,383). Depression/anxiety was diagnosed with the DSM-IV based Composite International Diagnostic Interview. The use of tricyclic antidepressants (TCAs), selective serotonin and noradrenalin reuptake inhibitors (SNRIs), and selective serotonin reuptake inhibitors (SSRIs) was established. T-wave amplitude and QT-interval corrected for heart rate (QTc) were obtained from an ECG measured in a type II axis configuration.
Results: Compared to controls, persons with depression or anxiety disorders did not show a significantly different TWA (p = 0.58; Cohen’s d = 0.046) or QTc (p = 0.48;
Cohen’s d = ?0.057). In spite of known sympathomimetic effects, TCA use (p = 0.26; Cohen’s d =?0.162) and SNRI use (p=0.70; Cohen’s d =?0.055) were not significantly
associated with a lower TWA. TCA use (p = 0.12; Cohen’s d = 0.225) and SNRI use (p = 0.11; Cohen’s d = 0.227) were also not significantly associated with a prolonged QTc.
Conclusion: We did not find evidence that either depressive/anxiety disorder or antidepressant use is associated with abnormalities in TWA or QTc. Earlier found sympathomimetic effects of TCAs and SNRIs are not evident in these measures of cardiac repolarization.