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Title: Cardiac Autonomic Nervous System Activity and Cardiac Function in Children after Coarctation Repair
Author(s): Ineke Nederend, Eco J.C. de Geus, Lucia J.M. Kroft, Jos J.M. Westenberg, Nico A. Blom and Arend D.J. ten Harkel
Journal: The Annals of Thoracic Surgery
Year: 2018
State: accepted
DOI: 10.1016/j.athoracsur.2018.01.084
File URL: /vuams-pubs/ANS children coarctic repair_Nederend et al.2018.pdf
Abstract: Background. Coarctation of the aorta (CoA) is one of the most common congenital heart defects. Due to improved surgical techniques, most patients live into adulthood. However, late complications including hypertension, recoarctation and arrhythmias are common. The autonomic nervous system (ANS) might play a role in the pathology. The aim of this study was to evaluate cardiac ANS activity and cardiac function in children after CoA repair and investigate the relationship between the two. Methods. 31 children after CoA repair and 62 healthy controls aged between 8 and 18 years old participated in the study. By the use of ambulatory impedance cardiography, cardiac ANS activity and cardiac output were measured for 24h. Cardiac function was measured by the use of transthoracic echocardiography and cardiac magnetic resonance imaging. Results. No group differences were found in ambulatory cardiac ANS. However ambulatory cardiac output and left ventricular function were significantly decreased in patients compared to controls. Conclusions. Left ventricular function and ambulatory cardiac output are impaired in patients after CoA repair, despite unchanged cardiac ANS activity in this group. These results underscore the importance of clinical follow up, even in patients without residual stenosis.

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