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Title: Vaccine-induced inflammation attenuates the vascular responses to mental stress
Author(s): Nicola J. Paine, Christopher Ring, JOS A. BOSCH, Mark T. Drayson, Sarah Aldred and Jet J.C.S. Veldhuijzen van Zanten
Journal: International Journal of Psychophysiology
Year: 2014
Month: September
Volume: 93
Issue: 3
Pages: 340-348
DOI: 10.1016/j.ijpsycho.2014.06.016
File URL: vuams-pubs/paine2014.pdf
Keywords: Interleukin-6; Tumor necrosis factor-alpha; Vascular blood flow; Mental stress
Abstract: Inflammation is associated with poorer vascular function, with evidence to suggest that inflammation can also impair the vascular responses to mental stress. This study examined the effects of vaccine-induced inflammation on vascular responses to mental stress in healthy participants. Eighteen male participants completed two stress sessions: an inflammation condition having received a typhoid vaccination and a control (non-inflamed) condition. Tumor necrosis factor-alpha and interleukin-6 (p's < .001) increased following vaccination, confirming modest increases in inflammation. Mental stress increased blood flow, blood pressure, heart rate, and cardiac output in both conditions (all p's < .001), but the blood flow response to stress was attenuated having received the vaccination compared to the control condition (p's < .05). These results further implicate the interaction between inflammation and the vasculature as a mechanism through which stress may trigger myocardial infarction.

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